Not really. I know people say it makes them lazy and unproductive, but I can smoke a fat bowl before bed and still have the motivation to lift the next day.
I've only lifted high once, the only real problem I had was I bottomed out on a squat and forgot how to get back up.
If you've ever squatted decently heavy weight you'd know there's a lot more to it then just squatting down then standing up. You have to concentrate on foot placement, knee position, back alignment, head alignment, core activation and timing all at the same time. I had about 250lbs on my back at the time and I wasn't intending to go that deep but I was too busy staring at myself in the mirror and next thing I know I'm bottomed out and there's no way I could atg that much normally, let alone while high.