Do people not know about the lore of this game? Guardians are not affected by cause and effect. They weave in and out of causality due to their power from the light. Nephalem from diablo while being the source of death itself are still bound by cause and effect, which makes them weaker in that regard. So just because of that, at this point in time there is no fictional character that can even compete with a guardian. As they aren't grounded in the basic laws of physics. This is why they were able to beat oryx, and why we can pierce through time and stop the restorative mind. We are in and out of time. Pretty sick actually. It's too bad they do a terrible job at representing this in the game. So I'll give you this. "In game mechanics" nephalem absolutely destroy guardians. Easy. Lore wise? Guardians are God's in the eyes nephalem.

You mean Asmodeus lol

Oh so that's what the heroes of Diablo are called.