Well in the real world, we know our reality isn't a simulation. The same could be said in game. Why? Irrational numbers of course (I'm sorry, it's the warlock in me)! Numbers such as pi and the square root of two are infinite as far as we keep calculating. In a simulation, someone would need to program that infinite number (impossible, in other words). Thus, no simulation. Not sure how this quite applies to Destiny, but it's fun to think about.