Mine has been in "The Summoning Pits" on Moon, called "The Untamed". Ridiculous health, constant high damage beams and never resting minion waves. It's not impossible, but if you get there low level and no back-up, better say your prayers haha
So, what's your most hated boss nemesis?
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My mom Rare boss but when she appears she usually makes my team wipe and lose a fireteam member. She also has the ability to take you off the game and break your PS3.