I originally thought the idea of using Hand Cannons during the Raid was preposterous. During the Conflux defense I decided to goof off and use mine. Little did I know, it wrecked goblins in a single critical shot!! Enemies don't seem as many, when they are disposed of so quickly.
During the Final Atheon, supplicants can be killed before they can make it off the Timegate.
Edit: Thanks for the responses!!
Edit 2: What's playing in your head upon reading the title courtesy of ClownKillingSOB
http://www.youtube.com/watch?v=MJLOCAWkRoc&sns=em
Edit 3: Over 700 response!! Who's ready for the DLC content! Looking for info on Trials of Osiris Hand Cannon right now
4:I haven't used a Hand Cannon during the new raid yet. It seems impractical as Vex and VoC are the most effective so far; Vex more so. Firefly could backfire on Fatebringer given the aggressiveness of thralls.
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Fatebringer is THE raid hand cannon. The best with ammo and the firefly perk is priceless. If you use it and you're on the templars confluxes you should be on center patrol. All those vex trying to come up the steps just get blown away from the fireflies explosion. It's definitely a rewarding type of weapon. Not many bullets in the chamber so make them count!