How do the nightfall strikes differ to the normal strikes on high difficulty?

You have multiple modifiers with it being heroic. The nightfall modifier makes it where if your whole team dies your sent back to orbit for example. Now that's not too bad, but add in mostly unique enemies and modifiers where they do increased melee DMG or they never flinch and it becomes hell. However, there's one where a certain element does more dmg

So similar to when you put a story mission on the highest difficulty