I worked on animation with pre-drawn sprites, so it's not completely new to me. However, animating frame by frame with self-drawn things is really difficult and time-inducing. I've tried it once, but will never get anything done unless I start drawing in really low detail. But that was years ago with a screen capture camera that combined frames into a single gif or mp4. Now I currently do not have a set up or program that lets me do that (such as Macromedia Flash or Sketchbook Pro 7).