Before you all get carried away with the potential scope of the game. Just remenber it is restricted by the current generation of console. It is being released on both old and new so obviously its not going to be akin to skyrim with hundreds of players. It's just not possible.
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You don't play with hundreds of players at a time. Bungie even says so in this article. http://m.joystiq.com/2013/02/17/bungie-reveals-destiny-an-always-on-persistent-world-adventu/