Mine is "If you ever fall for a woman, make sure she's got balls"--Buck, Halo 3 ODST.
[Edited on 02.17.2011 11:06 AM PST]
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Serina: This is all part of the plan right guys? followed by: Am I the only one freaked out that we're *inside* the planet? And Cortana: Keep your head down, there's two of us in here now. What can I say? I've got a thing for sarcastic AI's