For my favorite, probably the final part of GoW Ragnarok, when the music swells as Kratos blows the Gjallarhorn, and leads his army to Asgard.
My least favorite was when, during my first playthrough of Skyrim, I was informed I had to kill Paarthurnax.
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#Offtopic
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In Marathon when a Bob stopped in front of me and said, "I love you, man!" and walked on by. In Dues Ex when I was in a lab looking at bodies being created in vertical test tubes. I came to an empty one and looked down. The label had my name on it! Creeped me out - in a good way. Hated 343 taking over Halo. Really hate the remake of Duke Nukem. The original was fun and camp and now it's misogynistic garbage. Same with Bullet Storm; made it a swear fest.