Father Rodin - Bayonetta
Alpha-152 on highest difficulty - Dead or Alive 4
And several bosses in Soul Calibur 4 and 5 (Algol, Harada TEKKEN, Legendary Souls Mode, etc.)
Many high level opponents on higher difficulties in Fighting or Beat 'em Ups are just inhuman. And I'm actually quite good in these games.
English
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Alpha 152 is impossible for me on high difficulty