Do you kill them, ignore them or call for help while running like a pussy? Personally, I ask someone to deal with them. I can't kill them because they make me feel disgusting and because -blam!- insects. Only thing I can kill is mosquitoes.
I kill any and all with whatever opportunity provides me if I see one in my home. If it bugs me outside it better have an escape plan, otherwise I will kill it. I give spiders a little leeway for I know they are doing the job for me. But if they are visible in an obvious area, or a wolf spider, they die too.
I hate deer flys and mosquitoes.
We used to get yellow jackets building in our walls in the summer. I finally had enough of them chasing everybody, so I would go out in the evenings and smack them to bits with a badminton racket. After it was dark enough and they would not come out anymore I caulked their entry shut. They died.