I'm loving Destiny so far, but Chief is the pentacle of heroism! He's overcome countless obstacles on his own. The guardians seem really awesome but I don't think they could take the chief at his best! Yes, the guardians have "special" abilities, but remember what Chiefs special ability was.. luck. Lol how can you beat that? He's fought the flood, the covenant inclusive of tank like creatures (forgot their names, but they looked like Yetis lol), the elites, with their swords and invis, and all the rest! Every facet of the guardian's, The Chief has faced and defeated. And I didn't even mention the Didact and all the upcoming adventures. So all that being said, Chief would take the win! Not without some scars, but he'd undoubtedly win! Sorry for the Master Chief Anthology lol lol but I had to represent! Lol
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But he can be taken out by mysterious cones in Halo 2 multiplayer. Joking aside, MC would win in a solo Guardian fight. 3 on 1, I say 50 / 50 depending on Guardian team work and specials. A Skilled team would take him down in a few IMO.