The ps4 controller has been changed from the ps3, the sticks are further apart and the grips are longer. Im sure that if you give it long enough with resting in between that your hands will accustom to the difference.
Must say that ive used all sorts of controllers, megadrive, snes, dreamcast, gameboys, N64, gamecube, playstation and xbox.
The only controller that gave me trouble was the xbox's, finger cramps from the right trigger in driving and shooting games from the first xbox and some aching in the hand from 360 from prolonged use.
Until we get to try it we just dont know.
I reconmend giving them a try on the demo stalls when they arrive in stores.