Depends man. If you have a nvidia graphics card and it's fairly new you could use nvidias recording Software. Works great for games and only games games that I know of lol.
I have used a program called fraps and it's pretty nice and simple. You have to pay for though.
Honestly if you want the best answer. Ask on The forums of " toms hardware" great guys there. Would not say this is the best place lol
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If your recording game play them nvidia shadow play is the way to go. It gives you zero frame rate drop. But recording desktop stuff, I think fraps will work for it good. But don't take my word search and see.