I'm going with the Cazadors. I know in most of the areas the Cliff Racers come out of nowhere and swarm you. But at least they are easy to kill and even easier once you level up. But Cazadors on the other hand are just hell. They are fast and their attack and poison is strong. I know I was playing on very hard and I was around level 3, but I got rap3ed by a swarm in seconds. Hell even at level 35 I try to avoid them because I have trouble with them.
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Yeah, Cazadors. Never before in Fallout 3 did I ever think of making anti-venom for my characters...New Vegas changed that.
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I honestly never felt like Cliff Racers were much of a problem. They weren't hard to kill and their plumes got you 20 gold (score!). I have no idea what Cazadors are.
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Cazadors are assholes. And if you ever so happen to stumble into a group of Cazadors having conflict with a Deathclaw or two that then so happen to direct their assholeness towards you... -blam!-ing Cazadors.
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Oh God Cliff Racers. Anyone who says Cazadors has not seen the horrors of these things.