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In moderation, and with respect these substances can make you a radically better person. You've been tricked into thinking these substances, which have been used since the very beginning of human culture, are bad for you. Substances like psychedelic mushrooms might even be responsible for the ape mind doubling in size...
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Hey, I'm not saying that they don't have there downside, but they can if used correctly, permanently change the physical patterns in your brain in positive ways. I won't tell you that psychedelics can't harm you, but you also can't tell me that they have never benefited people.