Greetings, this is more of a feedback from my friends that joined D2 recently.
They all felt lost, some asked if the game had any kind of story or it was just farming events.
So I'd suggest the base campaign to be set for new players and after they are done direct then to the proper NPC to go for the other stories if they wish so.
Several stuff they required explanation:
How currency and material works, what glimmer does? Should I spend it whenever possible? There is a cap?
Same for Enhancement shards, Silver, Dust and Legendary Shards.
Have the NPCs to explain features if you wish to add some interactivity between the player and the game. Having Zavala telling about strikes even if is in a bit video gamish way. Same for Shaxx and so on. Have the Drifter to do a Drill camp before sending then to a Gambit lol.
That would increase how the new players feel welcome in the game.
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I also found it hard when first playing destiny. Even to this day some things still get me. Just have to guess or look on YouTube looolz