Mine has been in "The Summoning Pits" on Moon, called "The Untamed". Ridiculous health, constant high damage beams and never resting minion waves. It's not impossible, but if you get there low level and no back-up, better say your prayers haha
So, what's your most hated boss nemesis?
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Really? Telthor? He takes maybe 3 rockets to the face and goes down. If I were to answer this seriously though, Valus Tau'arc. Not because he's actually difficult but because he's the hardest to keep your patience with while you pump bullets in him. Hate that strike.