Mine has been in "The Summoning Pits" on Moon, called "The Untamed". Ridiculous health, constant high damage beams and never resting minion waves. It's not impossible, but if you get there low level and no back-up, better say your prayers haha
So, what's your most hated boss nemesis?
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This question is ridiculous. The only factor that matters is the level you are on, versus their level. Example: If you're level 26, facing a level 18, easy pickens. But if you're facing a 31, the challenge is greater.