It comes down to you. If you lower your defense, obviously you'll take a bit more incoming damage. If you feel the jump in strength is better than 7 more defense, I say go for it. I don't think it'll be insanely noticeable. Just compare the stats with the right trigger, button, what have you and see what you like and don't like. If the perks of having a better melee outweigh taking a bit more damage, then go with that. It's all up to you.
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Thanks, does the DEF of a weapon carry over to the crucible?
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Defense of your gaurdian and the attack of your weapon do not carry over to the crucible. In there, all those stats are normalized to an even playing field for everyone. So in there, those stats don't matter. Which also means a level one can best a 20 if his aim is good.