Honestly, I don't believe any of us would try it. Our ghost wouldn't be able to revive us at the beginning of the storyline because death was permanent.
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with all the reply's out there, sounds like a lot of people who give it a shot maybe once
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i was merely being facetious. It would be a fun mode as the suspense would make an already amazing game, that much more so. Only downside is falling off the map doing stupid stuff would be a crappy way to lose all that great gear :/