originally posted in:IGN
If you have access, to the first two I would say to start from the beginning. But if you only have the third one in your arsenal, I would say it's worth another play through. IMO the second is by far the best overall, but the third one has better gameplay mechanics (cover system and whatnot) and of course better visuals. It's been a while since I hopped on mass effect 3.
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What a great trilogy. I'm thinking about replying all three again. Glad bioware are doing mass effect 4!