From the footage and info we've seen so far on the enemies in Destiny, who looks to be the biggest pain in the ass to vanquish?...
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My butthole aka The Darkness.
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I answered vex. Since this is a random guess, in going to say that since the vex have a hydra, they will be the hardest to kill.
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None of the above. The most difficult race to kill is us.
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Vex have big units.
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I'm not rushing to fight the Cabal. They have to be the biggest pain.