Afaik, Linux is not supported because Destiny's anti-cheat wouldn't work correctly, in fact trying to play with Linux will almost certainly get you banned right away.
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D2 runs on Stadia which is Linux - based.
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Edited by Crisidelm: 1/28/2021 3:50:59 PMI think Stadia's Destiny 2 doesn't actually run natively on Linux though. And since it runs in a closed, trusted environment, that's okay with Bungie, of course.
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Low level hacking is pretty much off the table but more basic stuff like bots or aim hacks are still possible.