I was in my inventory about to use a Finest Matterweave, but I was also distracted and talking to a friend on discord. Instead of being hovered over the Finest Matterweave, I had Enhancement cores on the brain and naturally gravitated to them while holding 'F'.
Boom. 40 Masterwork cores. Gone.
Now, I recognize this was completely my own doing. However, I do find it frustrating that the most valuable currency in game can completely disappear with one action. Even Shaders are single delete, and you can literally buy them back from collections. There's honestly no reason these should even be discard-able, or at the very least they should discard one at a time like almost everything else in the game.
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The reason you can delete a whole stack of Cores at once is because there are no rewards given by deleting them. Shaders do give you glimmer/bright dust/legendary shards upon dismantling, which is why you can't just delete 978 shaders at once.