That's the thing. It isn't really a poison.
It's like being offered your favorite food to eat, but the problem isn't that it the food will give you food poisoning or that you've grown sick of it. The problem is that the food you once loved you can't taste anymore. Sure, you can try to change up the recipe or the food, but the problem remains. You can't taste.
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Well my point is in that situation people are responsible for their own health. If he noticed a change like this he should realise that something isn't right. Depression is a chemical inbalance alongside a psychological issue. And most people don't need pills they need change. People become unhappy in their current environment