Most vets took 2 weeks and the new guys maybe 4.
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About the 5th mission in. I'm thinking isn't there any new enemies. They are exactly the same with the same attacks as the first one. All of the bosses are just bigger versions of smaller enemies. The only 2 new enemy types added in were the skags from Borderlands and the little turret guys that aren't even there until the end and just a couple of them. I feel like they just took the first game, made new maps, tweaked the supers, and dumbed down the skill tree. It's really sickening that they had been working on this for years and that is all they came up with (I still believe they have more completed that they are selling as DLC). My biggest complaints are that it is wayyyyyy to easy to get Exotics. No more excitement of Gjallahorn, Vex, Hawkmoon, No Land, Jade Rabbit and so forth. It's look I got another exotic. Oh I haven't even played a total of 48 hours and you already have all the exotics. No rolls on the weapons which seems like a cop out to make their job easier, takes all replay-ability out of the game. Besides the fact that D1 had quest and strike specific gear, just in general I found them more fun. There were missions I liked to play. When I created a new character I just dreaded playing the missions again. I did like the tank one the first time I played it, but it is so annoying now. PVP I felt it after the first match. Just slow paced and boring now. The power weapons come and you get to have a couple seconds of fun.