It's hard to say, I was trying different loadouts and could not say, I tend to go Heavy Assault, Rocket and Frag. What changes things is the Hack Modules, and the armour one is what changes how effective a gun is imo. Favourite for me Heavy Assault at the moment.
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Wait... There are loadouts?!
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Yup, 3 the game gives you and 3 you can customise, you also have up to four Hack Modulles to utilise. EG, you can activate armour, or retribution or the ability to see how long until the next power weapon spawns, but, they come in different tiers, and don't last for the whole game, Doom looks like it's going to be very good imo.
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The Rocket Launcher is pretty good once you get the detonation timing right.
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I agree, and all the weapons have intersting LT abilities, they all are good for something.