There is a room that has a chest. If you don't have the relic and you attempt to get the chest you die from DOT. But with the relic you can walk up and grab it with no damage being done
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See my friend and I figured that one might be it, but we got he chest through creative means before it happened so we didn't check until after. Thanks for confirming it stops the "Taken Consumption" so you can get the chest.