I remember the auto-save bug from Morrowind back on the original xbox... I invested 100 hours into that game (at the time it was the most time I spent on a game, ever) and after the 100 hour mark the game would freeze every five minutes...
It was the beginning of my abusive relationship with Bethesda.
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Something like that happened to my brother in skyrim. He had over 80 hours on it, at 60, it would crash and be buggy. After 80, one day he turned it on to find out all his saves were deleted.