There are some regular hand cannons that can kill in two headshots, but there are a few conditions that have to be met.
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Yea but the only common example is the Timurs lash with specific perks or hawkmoon which both take forever to acquire
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There are actually more hand cannons with the same impact as Timur's Lash. Three examples I found were Painted Big Chief, Regulator, and Ill Will.
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But those arnt common examples like I said before