Personally, I think that hobgobs are, without a doubt, my most hated enemy.
Unless slain with pinpoint accuracy, and even then do they not always die from a crit shot with my trusty Fatebringer, will you dismiss them quickly, before they do their little mini-radiance-shield-bubble-fire thing.
Vex minotaurs no longer are my most hated because.... Well, because Swordbreaker.
Which enemy leaves you frustrated upon sight?
How do you decimate that yellow bar of HP?
Let me hear you, guardians.
Edit 1: Wow, 350+ replies in about 24 hours. I'm glad others share a hatred for a certain enemy, and the mix of replies being posted below certainly are comical. Thanks for posting!
Edit 2: we busted up through 650 replies. Didn't see this coming but it's still quite entertaining to see everyone's thoughts.
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1 Replyafter hundreds-thousands of hours (depends on the clock you look at I guess) I'm gonna go with RNG, I know xur had it week 2, while I was still a mere lvl 15 and had no strange coins to rub together, but I still have no gjallarhorn. and yet I've carried many first timers through the raids and several times they would get the gjallarhorn on their first vist to the exotic chest one of which was literally at hour 30 or so of playing the game. this i'm sure is RNGesus poke at my misfortune. so yes, to summarize my most hated enemy in Destiny is by far the RNG