I love the 501st, but their elite training would be the death of them. As the Flood create a grave mind, [i]all of the knowledge and skills of the 501st soldiers is integrated into it. [/i] In essence, the flood knows the 501st, and can easily destroy them.
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Not necessarily that would require the 501st to be infected
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And why is that so hard?
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Because of their armor suits and blaster rifles and elite training
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Weren't the forerunners well trained and armed?