Hey, I play mostly as a defender Titan, but lately I've switched over to striker. The reason is in the Crucible, I hate how I can out up my bubble for my teammates, fully upgraded to keep the people inside safe and the bubble is as strong as possible, and a Hunter will come along with one Golden Gun shot and take it down. I just think the whole Super thing in the Crucible between the classes is unbalanced. At least make it all three, in which case the supers are equal.
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Defender's good for the mag grenades, but that's about it. I find that my hunter is better in PVP.