Doesn't negatively effect game life, weapon perks, drops, ammo. Personally I think the RNG is a great thing, and it is very forgiving in this game as well. Try a little game called Path of Exile; First you have to get the specific item to drop (probably around a 5% chance if you are killing the right enemies in the right area), then you have to roll the 0.5% chance for it to be an orange (basically an exotic), then you have to hope you get the best roll on that item (One orange item may have +15% chance to bleed, and the exact same one with a different roll might have +25% chance to bleed, and you have to roll near the highest on up to 4 stats for the item to be worth your time), Then you have to use consumables in the hope of getting 6 skill slots on it (About a 2% chance), have to hope they are all the correct color (about a 5% chance), and have to hope they are all linked together (about a 5% chance again). So let me do the math here: You have a 6.25x10^(-10) chance of getting that item drop. Or, in other words: 0.000000000625% from each enemy you kill, Provided it is in the correct area. Stop your whining about destiny RNG

You sir are what is wrong with this game.