Be abducted by the Collectors (Mass Effect 2)

Be alone on a space station with a Xenomorph (Alien: Isolation)

Be one of the sole survivors of a nuclear apocalypse (Any Fallout game)

Be in the middle of a colony when the Borg invade (Star Trek Online)

Become part of the Insurgency...near the heart of Metropolis during Superman's Regime (Injustice)

Being a janitor during a zombie outbreak...while working for Atlas (COD: Advanced Warfare)