I think I have a tie between Native Son and The Great Gatsby. I swear if it wasn't for Sparknotes and Google I would've failed my Literature classes. I never even read a single chapter of any of those novels.
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I doubt this counts, but I had to watch the movie twilight in a lit/comp class once D: In terms of books though, I think it goes to the Scarlet Ibis for me. [Edited on 11.16.2012 7:08 AM PST]