I wanted to ask, if i use a disc of some other region on my ps4, will i lose my progress ?
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Your characters will be unaffected - characters are tied to your PSN account. As long as you log in with the same account, they will be there. You should note, however, that whole discs of any region will work on any Playststion, digital content is region locked. Furthermore, digital add ons for a game will not function, if your PSN account region differs from that of your disc: https://www.bungie.net/en/Help/Article/12459