Personally, I think that hobgobs are, without a doubt, my most hated enemy.
Unless slain with pinpoint accuracy, and even then do they not always die from a crit shot with my trusty Fatebringer, will you dismiss them quickly, before they do their little mini-radiance-shield-bubble-fire thing.
Vex minotaurs no longer are my most hated because.... Well, because Swordbreaker.
Which enemy leaves you frustrated upon sight?
How do you decimate that yellow bar of HP?
Let me hear you, guardians.
Edit 1: Wow, 350+ replies in about 24 hours. I'm glad others share a hatred for a certain enemy, and the mix of replies being posted below certainly are comical. Thanks for posting!
Edit 2: we busted up through 650 replies. Didn't see this coming but it's still quite entertaining to see everyone's thoughts.
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-blam!-in hive boomers and thier sniper ways. More than once have they made me rage quit on crotas end hard when they continuously knock someone off with one well placed homing electro explodey rounds