Hi there,
Please check out our Audio Guide to ensure the in-game settings as well as your console settings are optimized for Destiny 2:
https://help.bungie.net/hc/en-us/articles/360049196431-Destiny-Audio-Guide
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I have checked all these settings multiple times, they are all correct but it does not fix the problem. My mic icon has an x almost all of the time. Occasionally it will allow me to voice chat in-game but it is extremely rare.