Running D2 on a 144hz 1440p monitor on a RX480 8GB with above 100FPS here, I noticed that stutters would show up and be most annoying while playing PvP.
I tried the 'turn off Steam friends' fix and it seemed to work for me. Still no permanent solution since steam friends are important to me to see whos up for raids etc..
Setup
CPU AMD Ryzen 5 2600X
GPU RX480 8GB
RAM 16GB
WIndows 10
Monitor HP 27xq 144hz 1440p
English
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I have the issue in PvP as well. It started last night out of the blue. Smooth as butter in orbit, but once I drop into a pvp game it stutters to no end. GTX 1070, i7 6700K, 32gb ram. Haven’t changed anything from the last time I played except going from 16 to 32 ram. Either something in the weekly reset or for some odd reason the ram upgrade did it, which wouldn’t make sense. Going to give the steam friends fix a try later today, I really hope it works. It’s a dumb fix but the stuttering is near unplayable.