The game has to have built in support for keyboard and mouse. Destiny doesn't I believe. Only game I can think of that does for PS4 is Final Fantasy 14
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There are ways to key bind the mouse and keyboard even without the game options supporting it.
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Only with an external device. But even then you won't really have an advantage. You'll be mapping the joystick to mouse movements. It won't control like a proper mouse supported game.
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War thunder :D