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maybe they're a hermaphrodite?
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My friend is one, but she clearly looks like a female.
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Trans?
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Call them by what they identify with.
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Sometimes, that can be hard to figure out...
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Hmmm OK, still "it" sounds very rude. It's like your referring to your cat or dog.
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Some trans don't identify though.
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Then I just roll with what's between their legs.