Honestly, Mass Effect 3.
Its refined combat and weapon mechanics made the game so much more enjoyable from a simple gameplay perspective. It also had a really fun and intense story that was great until the last 10 minutes. I'm not going to let those 10 minutes ruin the whole game for me.
Also, ME3 had the best DLC overall and a fun multiplayer.
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Overall, ME2 ME3 has the best weapons/power/upgrade system. Also great multiplayer. ME2 and ME3 the with dlc. ME2 had the best ending. ME1 had a great build up to its end.
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Plus, the ending was okay with extended cut