Nova bomb can't take down majors (grrrr) so I wittle adds with guns, then with obsidian mind, boom, nova bomb. Obsidian mind is quite good if you can wittle the enemy health bars down before hand.
Add bad juju. Profit.
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Yea no doubt obsidian mind is a beast in pve...nova bomb into a bunch of adds and boom just about halfways to ur next nova bomb. Especially good if u have a nightstalker in the group... Tether then nova bomb and then ull probably have ur nova bomb ready again