Mine has been in "The Summoning Pits" on Moon, called "The Untamed". Ridiculous health, constant high damage beams and never resting minion waves. It's not impossible, but if you get there low level and no back-up, better say your prayers haha
So, what's your most hated boss nemesis?
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Before the dlc at the forgotten shore in the basement of that building, where now is the entrance to Rasputin, there were three knights, one of them was worse than Randal!!! It-just-would-not-die!! Hardest fight yet! When he was finally down there was nothing else there than a dead ghost shell. He didn't even drop something... Typical...