When you reset your exotic weapons the damage starts at 302. So although you will have to work for the perks again, the damage will be higher at new "stock" lvl.
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The higher base damage means little if you lost all the weapons perks. You'd rather have a 302 gjallarhorn without wolfpack perk? Or a 302 icebreaker without ammoregen?
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It doesn't take long to rank them back up and without needing ascendant materials anymore it should be very easy to rank them back to the perks.
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You know you can still get those perks right?