I originally thought the idea of using Hand Cannons during the Raid was preposterous. During the Conflux defense I decided to goof off and use mine. Little did I know, it wrecked goblins in a single critical shot!! Enemies don't seem as many, when they are disposed of so quickly.
During the Final Atheon, supplicants can be killed before they can make it off the Timegate.
Edit: Thanks for the responses!!
Edit 2: What's playing in your head upon reading the title courtesy of ClownKillingSOB
http://www.youtube.com/watch?v=MJLOCAWkRoc&sns=em
Edit 3: Over 700 response!! Who's ready for the DLC content! Looking for info on Trials of Osiris Hand Cannon right now
4:I haven't used a Hand Cannon during the new raid yet. It seems impractical as Vex and VoC are the most effective so far; Vex more so. Firefly could backfire on Fatebringer given the aggressiveness of thralls.
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i'm a pistol specialist (i've used all the ones i'm listing i haven't used all the hand cannons) and i recommend , The Devil You Know (vanguard hand cannon, 12-13 shots [GREAT SIDE ARM]), lord high fixer (crucible hand cannon, 11-13 shots [good but slow reload [it could be better but the version i used didn't have any reload up so ah] Last word (LOVE IT 8 shots hip fire just about equal to aiming down the sight) and that's all i hope this helps someone and i hope to see more hand cannon users. :) see yea everyone