In my opinion, the mass effect series tops it due to its amazing writing and story driven nature. However, it's rpg elements were not as strong as some other titles, so which one did you enjoy the most?
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1. Fallout New Vegas (Better guns and gear than 3) 2. Fallout 3 3. Oblivion 4. Skyrim (Way better game engine than the rest of the games I've mentioned, but it's newer.)